Aeromics is a clinical stage drug development company developing Aquaporin inhibitors for the treatment of cerebral edema in stroke, based on pioneering discoveries by Dr. Peter Agre (2003 Nobel Prize in Chemistry). Cerebral edema is predictive of patient outcome in ischemic strokes, and yet there are no approved therapeutics that effectively target and treat cerebral edema as a causal driver of stroke severity. Despite the vital role of aquaporins in maintaining water homeostasis and its implications in various disease states, therapeutic agents targeting aquaporins have remained elusive until now. Aeromics’ drug candidate, AER-271, targets aquaporin-4 (AQP4), the primary water channel in the brain, and has best-in-class credentials for acute intravenous therapy for stroke-related cerebral edema. AER-271 has proven pharmacology demonstrating control of cerebral edema in models for ischemic stroke, cardiac arrest, and water toxicity.

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