Christopher Colecchi is the Managing Director of Broadview Ventures. Chris leads the Broadview investment team and operations, and coordinates the activities of Broadview’s Strategic Advisory Board.
Previously, Chris was the Vice President for Research Ventures and Licensing at Partners Healthcare – an integrated health system founded by the Harvard-affiliated Brigham and Women’s Hospital and Massachusetts General Hospital. Chris led business development, technology transfer, and commercialization activities at Partners and managed efforts to establish strategic alliances with the life sciences industries. He also created the Partners Innovation Fund – a venture capital fund that makes investments in early stage companies emerging from Partners hospitals.
Earlier in his career, Chris was the Director of Clinical Trials and Industrial Relations for the Massachusetts General Hospital and Director of Clinical Monitoring for a clinical research organization at which he oversaw the set-up and management of multi-center, industry-sponsored clinical trials at several hundred sites throughout the U.S. and Canada. Within these roles, Chris worked directly with most of the major international pharmaceutical and biotechnology companies as well as many in the device arena.
Chris currently serves on the boards of CellAegis, GI Windows, Ground Fluor Pharma, and InfoBionic.
Outside of Broadview, Chris serves as a board member of the University of Massachusetts School of Public Health and Health Sciences, the Massachusetts Association for Mental Health, the Baim Institute for Clinical Research, and the Institute for Cardiovascular Research and Science founded by the Royal Brompton and the Liverpool Heart and Chest Hospitals.
Chris holds a B.A. from Holy Cross College and an M.P.H. from the University of Massachusetts School of Public Health. He lives in Andover, Massachusetts with his wife, Kathy, and three children, Benjamin, Talia and Joseph.
Maria Berkman, MD, MBA, is a Director, and Head of the MedTech practice at Broadview Ventures.
Maria shares responsibility for all aspects of Broadview’s investment activity, from identification and screening of new opportunities, through due diligence, negotiation of deal structure, and portfolio company board involvement.
Prior to joining Broadview Ventures, Maria was a management consultant at Monitor Group (now Monitor Deloitte), where she specialized in life sciences with a focus on corporate, franchise, and asset-level commercialization strategy and competitive strategic planning for a broad range of BioPharma and MedTech clients. Prior to joining Monitor Group, Maria trained within the Partners HealthCare System at Newton Wellesley Hospital in General Surgery. Maria earned an MD from the UCLA School of Medicine, graduating Alpha Omega Alpha with a research focus in cardiothoracic and trauma surgery, and earned an MBA from the Anderson School of Management at UCLA.
Maria serves on the boards of 480 Biomedical, Apama, BioKier, Cardero, Cardialen, FineHeart, Vascular Graft Solutions and Zumbro Discovery.
In addition to her role at Broadview Ventures, Maria contributes time as a SBIR/STTR grant reviewer for the National Science Foundation and is a Strategic Advisory Board Member for the RAD BioMed Accelerator in Tel Aviv, Israel.
Christopher de Souza, PhD, MBA, is a Director at Broadview Ventures. He brings to this role over 20 years experience in cardiovascular and metabolic related biopharmaceutical R&D, corporate strategy and business development.
Christopher started his pharmaceutical career at Novartis as a senior scientist in the Metabolic and Cardiovascular Diseases group and then as Director of Strategic Alliances with responsibilities for therapeutic area strategy, business development and alliance management. After Novartis, Christopher was Vice President of Business Development at SkyePharma US Inc., a drug delivery company, where he was responsible for out-licensing the company’s clinical assets and drug delivery technologies. Christopher also founded a business development consulting practice with several clients including JSB-Partners, Diagnostics For All and Metaome.
Christopher received a Masters in zoology from the University of Bombay, a PhD in physiology from Louisiana State University and an MBA from Rutgers University. He completed his post-doctoral training at The Upjohn Company and the Joslin Diabetes Center/Harvard Medical School.
Christopher currently serves on the boards of Acesion, Allosteros, DecImmune, Gila Therapeutics, Pulmokine and VentriNova.
Outside of Broadview Ventures, Christopher serves on the board of MassBio and on the grant review committees of the British Heart Foundation and NIH/NHLBI.
As the inaugural Chief Scientific Officer at the Leducq organization, Dr. Mariell Jessup advises Broadview on its investments and portfolio activities.
Dr. Jessup was most recently a Professor of Medicine at the University of Pennsylvania’s Perelman School of Medicine where she also served as the Medical Director of Penn’s Heart and Vascular Center and Clinical Chief of the Cardiovascular Division until July 2015.
Dr. Jessup’s focus throughout her career has been translating new therapies for and the optimal management of patients with heart failure, including the appropriate selection of patients for heart transplant or ventricular assist devices (VADs). The foundation for these clinical activities continues to be discovery science and clinical trials.
Dr. Jessup has been a long-time volunteer of the American Heart Association (AHA), having served as the Chair of the Committee for Scientific Sessions Program, and as a member of the Board of Directors of the national AHA, before becoming President of the American Heart Association in 2013.
In addition to publishing numerous articles, editorials, reviews, and chapters on heart failure and heart transplant, Dr. Jessup was a clinical investigator in many landmark clinical trials in heart failure. For example, she led the first-in-man study using the gene for SERCA2A.
Frederick “Rick” Jones, MD, is a Director at Broadview Ventures.
Rick shares responsibility for all aspects of Broadview’s investment activity, from identification and screening of new opportunities, through due diligence, negotiation of deal structure, and portfolio company board involvement.
Prior to joining Broadview, Rick founded Spordiff Therapeutics, which was developing a small molecule to prevent C. difficile infection. Previously, Rick was CEO of Anchor Therapeutics, a venture-backed company developing a platform of lipidated peptides targeting intractable GPCR targets. Before that Rick held increasingly responsible positions as a general manager, business development professional and medical affairs officer with Devgen, BioRexis and Wyeth Pharmaceuticals. Early in his career, Dr. Jones practiced internal medicine, most recently as Assistant Professor in the University of Pennsylvania health system. Rick earned his BA, MD and MBA degrees from the University of Pennsylvania.
Rick serves on the boards of Aggamin, Remedy, ZZ Biotech, Ischemia Care and Aeromics.
In addition to his role at Broadview, Rick sits on the Scientific Advisory Board of the Massachusetts Life Sciences Center and is a member of the StrokeNet External Oversight Board at NINDS.
Benjamin Kreitman broadly supports the Broadview investment team in its day-to-day operations, including identification and screening of new opportunities, due diligence, negotiation of deal structure, and portfolio company involvement.
Prior to joining Broadview, Benjamin was a Consultant at Monitor Deloitte, the strategy management consulting arm of Deloitte Consulting, LLP. At Monitor Deloitte, Benjamin worked alongside senior executives on a variety of engagements including commercial strategy development for biotechnology startups as well as global pharmaceutical and medical device manufacturers, and corporate development and investment due diligence across a number of industries.
Benjamin earned undergraduate degrees in Biological Sciences and Financial Economics Magna Cum Laude from Columbia University.
Nichole Neal, MBA is the Manager of Operations at Broadview Ventures.
Nichole manages day-to-day business operations, office administration, triaging of incoming investment opportunities, and meeting and event planning. Nichole also supports the investment team in its day-to-day operations.
Prior to joining Broadview Ventures, Nichole was the department administrator for both the Cardiovascular Program (Heart Center) and the Medicine Intensive Care Unit at Boston Children’s Hospital. There, Nichole worked alongside the Vice President of Critical Care Services and was responsible for overseeing business operations, managing and coaching administrative staff, developing and implementing best practices, and improving processes and compliance in support of the organization’s mission.
Nichole earned an MBA in Business and Healthcare Management from the University of Phoenix and an undergraduate Bachelor of Science degree in Healthcare Management and Policy from the University of New Hampshire.
Strategic Advisory Board
EUGENE BRAUNWALD, M.D. is the Distinguished Hersey Professor of Medicine at Harvard Medical School, and the founding Chair of the TIMI Study Group at the Brigham and Women’s Hospital.
Dr. Braunwald received his medical training at New York University and completed his Medical Residency at the Johns Hopkins Hospital. He served as the first Chief of the Cardiology Branch and as Clinical Director of the National Heart, Lung and Blood Institute, founding Chairman of the Department of Medicine at the University of California, San Diego. From 1972 to 1996 he was Chairman of the Department of Medicine at the Brigham and Women’s Hospital. He was a founding trustee and Chief Academic Officer of Partners HealthCare System.
Dr. Braunwald’s first major paper was published in Circulation Research in July 1954, and he has been a major force in cardiology in the past half century. His early work focused on the control of ventricular function and he was the first to measure both left ventricular ejection fraction and left ventricular dp/dt in patients. His group showed the first neurohumoral defect in human heart failure, defined the pathophysiology of hypertrophic cardiomyopathy and demonstrated salvage of ischemic myocardium following coronary occlusion. They defined myocardial stunning and ventricular remodeling following myocardial infarction. For the past 30 years, he and his colleagues at the TIMI Study Group demonstrated improved patient survival with a patent coronary artery which led to the widely accepted “open artery hypotheses.” They were the first to show the benefit of preventing adverse remodeling of the infarcted ventricle with ACE inhibition. In the PROVE-IT TIMI 22 Trial, in 2004, they demonstrated the benefit of more intensive reduction of LDL in high risk coronary artery patients, which has changed practice guidelines and will favorably affect the lives of millions.
Dr. Braunwald has been an editor of Harrison’s Principles of Internal Medicine for 12 editions, and the founding editor of Heart Disease, now in its 10th Edition, the most influential textbooks in their fields.
Science Watch listed Dr. Braunwald as the most frequently cited author in Cardiology; he has an H index of 204. Based on his contributions, Dr. Braunwald has received numerous honors and awards including the Distinguished Scientist and Lifetime Achievement Awards of the American College of Cardiology, Research Achievement, and Herrick Awards of the American Heart Association, the Gold Medal of the European Society of Cardiology and is the recipient of twenty two honorary degrees from distinguished universities throughout the world. The American College of Cardiology has established an annual lecture in his name. The European Society of Cardiology, Heart Failure Association has established an annual lecture in his name. Dr. Braunwald was the first cardiologist elected to the National Academy of Sciences of the United States. The living Nobel Prize winners in medicine voted Dr. Braunwald as “the person who has contributed the most to cardiology in recent years”.
Professor Kim Fox
Kim Fox, MD is Professor of Clinical Cardiology and Head of the National Heart and Lung Institute at Imperial College London. He is also Diana, Princess of Wales Chair in Cardiovascular Medicine and Science and Consultant Cardiologist at the Royal Brompton Hospital. Professor Fox is also a non-Executive Director of the Royal Brompton and Harefield NHS Foundation Trust as well as a Trustee of the Institute of Cardiovascular Medicine and Science, Magdi Yacoub Institute, and National Heart and Lung Institute Foundation.
He was President of the European Society of Cardiology 2006-2008, having previously been Treasurer and Secretary. He was Associate Editor of the British Heart Journal in 1985-1994 and Editor in Chief of the European Heart Journal 1994-2002. He has previously served as a member of the British Heart Foundation Education Committee (chair), Council and Executive Committee as well as the British Cardiac Society’s Council and Medical Practice Committee (chair).
Professor Fox has published over 500 papers in leading scientific journals. His expertise is in the understanding, investigation and treatment of angina; in particular the role of heart rate in the pathophysiology of myocardial ischaemia and infarction. He has played a major role in many important international clinical trials (EUROPA, IONA, BEAUTIFUL, HPS, ASCOT, SEARCH, PERFORM, SIGNIFY, etc) that have changed the treatment of this condition. He chaired the Task Force producing the European Angina Guidelines and chaired the committee responsible for the audit for the management of these patients in Europe.
Professor Fox has given plenary lectures to National Societies all over the world. He has given the “Finlayson Lecture” to the Royal College of Surgeons in Glasgow, the “St Cyres Lecture” to the British Cardiac Society, the “Andrea Cissalpino Lecture” to the Italian Cardiac Society and the “Stokes Lecture” to the Irish Cardiac Society. Professor Fox has been elected an honorary member of the French Cardiac Society and Japanese Circulation Society for his services to cardiology. He has been awarded the Mackenzie Medal of the British Cardiovascular Society, the Gold Medal of the European Society of Cardiology, the Chazov Medal of the Russian Federation of Cardiology and the Stokes Medal of the Irish Cardiac Society.
Thomas Hughes, PhD
Dr. Hughes has over 25 years of experience in pharmaceutical research and development. Dr. Hughes joined Zafgen in 2008 as president, chief executive officer and a member of the company’s board of directors. From 1987 to 2008, Dr. Hughes held several positions at Novartis AG (and formerly Sandoz Pharmaceuticals) including vice president and global head of the cardiovascular and metabolic diseases therapeutic area at the Novartis Institutes for BioMedical Research in Cambridge, MA. In these roles he oversaw many drug discovery and development projects targeting obesity, diabetes, and heart disease. As a scientist, Dr. Hughes led Novartis’ efforts to discover and develop its dipeptidylpeptidase IV inhibitor vildagliptin (Galvus®/Eucreas®), a drug used for the treatment of type 2 diabetes, currently approved in 70 countries. Dr. Hughes is the author of over 40 peer-reviewed publications and is an inventor on numerous issued and pending patents related to the treatment of diabetes, cardiovascular disease, and obesity.
Dr. Hughes also serves as a director on the board of Miragen Therapeutics, Inc., and is a member of several scientific and strategic advisory boards, including Broadview Ventures and Nimbus Discovery, LLC.
Costantino Iadecola, M.D.
Anne Parrish Titzell Professor of Neurology
Director (Chair) Feil Family Brain and Mind Research Institute
Weill Cornell Medical College, New York
Dr. Iadecola is a clinician-scientist who is an internationally recognized expert in the field of cerebrovascular diseases and dementia. Dr. Iadecola received an MD degree from the University of Rome, Italy, and completed Neurology Residencies both at the University of Rome and at New York Hospital-Cornell Medical Center, New York, NY.
After completing his training, Dr. Iadecola joined the Department of Neurology of the University of Minnesota, where he rose through the academic ranks serving as Professor and Vice-Chair for Research. In 2001, Dr. Iadecola was recruited back to Cornell as the G. C. Cotzias Distinguished Professor of Neurology and Neuroscience, and Director of the Division of Neurobiology. In 2012 Dr. Iadecola was appointed Anne Parrish Titzell Professor of Neurology and Director of the Feil Family Brain and Mind Research Institute, a new Department at Weill Cornell focused on basic and translational neuroscience research.
Dr. Iadecola’s research focuses on the brain dysfunction and damage that underlie two of the most devastating brain diseases: stroke and dementia. A particular area of interest is how cerebrovasclar diseases cause cognitive impairment and the overlap between vascular cognitive impairment and Alzheiemer’s disease. Dr. Iadecola has published over 300 papers in peer-reviewed journals. He is active in several national and international research organizations and funding agencies, including the NIH, the American Heart Association (AHA) and the Alzheimer’s Association. He has served on the Research Committee and on the Stroke Council of the AHA and chaired the Program Committee of the International Stroke Conference. He participates in focus groups and review committees at the NIH. He has been President (Chair) of the Scientific Advisory Committee of the Fondation Leducq and is an advisor to the European Stroke Networks, the Institute of Stroke and Dementia Research (Munich, Germany), the Cluster for Systems Neurology (Munich, Germany), the Hotchkiss Brain Institute (Calgary, Canada), the DHU NeuroVascular disease Sorbonne (Paris, France), and the TargetBrain European Union Consortium. Dr. Iadecola has served as Associate Editor (2000-2010) and Consulting Editor for the AHA journal Stroke, and Reviewing Editor for the Journal of Neuroscience, the official journal of the Society for Neuroscience. He serves as Guest Editor for Hypertension, Circulation and for the Proceeding of the National Academy of Sciences. He is a member of the editorial board of the Annals of Neurology, Circulation Research, Cerebrovascular Diseases, Cellular and Molecular Neuroscience, and the Journal of Cerebral Blood Flow and Metabolism.
Dr. Iadecola has received the McHenry Award from the American Academy of Neurology, the Louis Sklarow Memorial Award, the Established Investigator Award (AHA), two Jacob Javits Awards from NINDS/NIH (1999, 2015), the Willis Award, the highest honor in stroke research bestowed by the AHA, and the Zenith Fellow Award from the Alzheimer’s Association in recognition of his work on the role of vascular factors in Alzheimer’s dementia. In 2015 Dr. Iadecola was awarded the Excellence Award in Hypertension Research by the Hypertension Council of the AHA for his studies on the role of high blood pressure in promoting both vascular cognitive impairment and Alzheimer’s disease. In 2015 he was elected to the Association of American Physicians. He is the principal investigator of several NIH grants.
Argeris “Jerry” Karabelas, PhD
Dr. Karabelas is a Partner at Care Capital, LLC, a life sciences venture firm with $500MM under management. He is the Chairman of the Board of Polyphor Ltd., which is focused on developing innovative drugs based on its proprietary macrocycle technologies. He is also a member of the board of RegenXbio, a publicly traded gene therapy company; a member of the board of Valeant Pharmaceuticals, a public company; and a member of the board of Braeburn Pharmaceuticals, a privately held company focusing on treatments for addiction and pain. Dr. Karabelas is also a member of the Strategic Advisory Board of Broadview Ventures.
Previous to these positions, Dr. Karabelas founded the Novartis Bio Venture Fund; was the CEO of Worldwide Pharmaceuticals, Head of all Healthcare Businesses and member of the Executive Committee at Novartis, AG; was Executive Vice President of Pharmaceuticals at SmithKline Beecham, Chairman of the Pharmaceutical Executive and Development Committees, and a member of the Executive Committee of SmithKline Beecham. Previous to these senior executive positions, Dr. Karabelas had a typically progressive career in pharmaceutical sales and marketing at SmithKline and French. He was also a Professor of Pharmacokinetics.
Dr. Karabelas has founded several companies: CytoTherapeutics, Inc., Vanda Pharmaceuticals Inc., and Minerva Pharmaceuticals. He is former Chairman of Human Genome Sciences, Vanda Pharmaceuticals Inc., Renovo, NitroMed, Inc., and SkyePharma plc.
Dr. Karabelas holds a Ph.D. in Pharmaceutical Sciences and Pharmacokinetics from the Massachusetts College of Pharmacy and a Bachelor of Sciences in BioChemistry from the University of New Hampshire.
Martín Landaluce is the President of the Fondation Leducq Board of Directors, where he has served as a member for over 20 years. He oversees the investment and spending policies of the Leducq Trust, and with David Tancredi represents the trust on the Broadview Board of Directors. Mr. Landaluce grew up and was educated in Madrid, and is currently a resident of London.
Joseph Loscalzo, M.D., Ph.D.
Hersey Professor of the Theory and Practice of Medicine
Harvard Medical School
Chairman, Department of Medicine
Brigham and Women’s Hospital
Dr. Joseph Loscalzo is Hersey Professor of the Theory and Practice of Medicine at Harvard Medical School, Chairman of the Department of Medicine, and Physician-in-Chief at Brigham and Women’s Hospital. Dr. Loscalzo received his A.B. degree, summa cum laude, his Ph.D. in biochemistry, and his M.D. from the University of Pennsylvania. His clinical training was completed at Brigham and Women’s Hospital and Harvard Medical School, where he served as Resident and Chief Resident in medicine and Fellow in cardiovascular medicine.
After completing his training, Dr. Loscalzo joined the Harvard faculty and staff at Brigham and Women’s Hospital in 1984. He rose to the rank of Associate Professor of Medicine, Chief of Cardiology at the West Roxbury Veterans Administration Medical Center, and Director of the Center for Research in Thrombolysis at Brigham and Women’s Hospital. He joined the faculty of Boston University in 1994, first as Chief of Cardiology and, in 1997, Wade Professor and Chair of Medicine, Professor of Biochemistry, and Director of the Whitaker Cardiovascular Institute. He returned to Harvard and Brigham and Women’s Hospital in 2005.
Dr. Loscalzo is recognized as an outstanding cardiovascular scientist, clinician, and teacher. He has received many awards, including the Clinician-Scientist Award, the Distinguished Scientist Award, the Research Achievement Award, and the Paul Dudley White Award from the American Heart Association; a Research Career Development Award, a Specialized Center of Research in Ischemic Heart Disease Award, and a MERIT Award from the National Institutes of Health; the George W. Thorn Award for Excellence in Teaching at Brigham and Women’s Hospital, the Educator of the Year Award in Clinical Medicine from Boston University, and the William Silen Lifetime Achievement in Mentorship Award from Harvard Medical School; the Glaxo Cardiovascular Research Award, and the Outstanding Investigator Prize from the International Society for Heart Research; election to fellowship in the American Association for the Advancement of Science, and in the American Academy of Arts and Sciences; and election to the American Society for Clinical Investigation, the Association of American Physicians, and the National Academy of Medicine. Castle Connolly has named him one of America’s Top Doctors. He served as an associate editor of the New England Journal of Medicine for nine years, Chair of the Cardiovascular Board of the American Board of Internal Medicine, Chair of the Research Committee of the American Heart Association, Chair of the Scientific Board of the Stanley J. Sarnoff Society of Fellows for Research in the Cardiovascular Sciences, and Chair of the Board of Scientific Counselors of the National Heart, Lung, and Blood Institute of the National Institutes of Health. He is a former member of the Advisory Council of the National Heart, Lung, and Blood Institute, and a former member of the Council of Councils of the National Institutes of Health. He is currently Director of the NIH-funded Center for Accelerated Innovation (the Boston Biomedical Innovation Center), the NIH-funded Harvard Undiagnosed Disease Network program. He is also former Editor-in-Chief of Circulation, and a current senior editor of Harrison’s Principles of Internal Medicine.
Dr. Loscalzo has been a visiting professor at many institutions, holds two honorary degrees, has authored or co-authored more than 900 scientific publications, has authored or edited 41 books, and holds 31 patents for his work in the field of nitric oxide and redox biology. He is also the recipient of many grants from the NIH and industry for his work in the areas of vascular biology, thrombosis, atherosclerosis, and, more recently, systems biology over the past thirty years. His most recent work has established the field of network medicine, a paradigm-changing discipline that seeks to re-define disease and therapeutics from an integrated perspective using systems biology and network science.
Eric A. Rose, MD is Chairman of the Broadview Strategic Advisory Board. He is an academic physician and entrepreneur with interests in drug discovery, biodefense, clinical evaluative research and health policy. He is the Executive Chairman of Siga Technologies, Inc., the developer of an orally bioavailable smallpox anti-viral drug which is being added to the US Strategic National Stockpile.
He is a Professor of Population Health Science, Cardiac Surgery, Surgery, and Cardiology at the Mount Sinai School of Medicine since 2008. From 1994 through 2007, he served as Surgeon in Chief at New York-Presbyterian Hospital/Columbia and Chairman of the Department of Surgery at the Columbia University College of Physicians and Surgeons, where he held a distinguished professorship.
An accomplished heart surgeon, researcher and entrepreneur, Dr. Rose grew one of the nation’s premier departments of surgery while managing, investigating and developing complex medical technologies ranging from heart transplantation and novel approaches to Alzheimer’s disease to bioterrorism. He has authored or co-authored more than 300 scientific publications and has received more than $25 million in NIH support for his research.
Dr. Rose pioneered heart transplantation in children, performing the first successful pediatric heart transplant in 1984, and has investigated many alternatives to heart transplantation, including cross-species transplantation and man-made heart pumps. Siga has received more than $100 million in federal research support since he joined the company, developing anti-viral drugs for smallpox, dengue, and Lassa fever. He received both his undergraduate and medical degrees from Columbia University.
David Tancredi, MD, PhD
David Tancredi is the President of Broadview Ventures, and the Executive Director of the Fondation Leducq in Paris, France. With Martín Landaluce, he represents the interest of the Leducq Trust on the Broadview Board of Directors. A graduate of Harvard Medical School, Dr. Tancredi completed a residency in emergency medicine at the University of Cincinnati before obtaining a Ph.D. in sociocultural anthropology from the University of Chicago.
Annabel Chen-Tournoux, MD, is an advisor to Broadview Ventures, where she was formerly a member of the operations team. With a research background in biomarkers, cardiac imaging, and stem cell delivery strategies, she has a strong interest in translational research in cardiovascular disease.
Dr. Chen-Tournoux received her medical degree from Harvard Medical School and completed her internal medicine and cardiology training at Massachusetts General Hospital. She was a Senior Program Director at the Fondation Leducq in Paris for three years, where her responsibilities included management of the foundation’s grant programs and public communications. In 2012 she joined the Division of Cardiology at McGill University as a Clinical Assistant Professor at the Jewish General Hospital.
Forcht (Teo) Dagi, MD, MPH, MBA, DMedSc, DHC, FRCSEd is a neurosurgeon and neuro-intensivist, a veteran venture capitalist and board director with extensive international experience in public service. He has helped raise over $700 million in funds for portfolio companies and venture capital funds and has more than 15 years of successful experience in founding, managing and exiting companies in health care services and in the life sciences. He has operating experience in healthcare services, healthcare information technology and the biomedical sector, and he has served on boards of directors of publicly traded and privately held companies including. His portfolio has included AtheroGenics, Inc (Nasdaq: AGIX); Inhibitex, Inc. (Nasdaq: INHX, acquired by Bristol-Myers-Squibb); Synageva, Inc. (acquired by Alexion); Trivirix, Inc. (acquired by Nortel); Encelle, Inc. (acquired by Pioneer Surgical); Teladoc (NYSE: TDOC); and Merix Biosciences (now Argos Therapeutics, Nasdaq: ARGS). He has also chaired or served on the scientific advisory boards of Dupont Pharma, Lundbeck, the Royal Bank of Canada and other private and publicly listed companies.
Dr. Dagi serves as Distinguished Scholar and Professor at Queen’s University Belfast, Northern Ireland (UK), and a Scholar in the Academy at Harvard Medical School. He is past chair of the International Advisory Panel of the Queen’s School of Medicine. He is immediate past chair, and a Director of the Committee on Perioperative Care of the American College of Surgery the Council for Surgical and Perioperative Safety and the Anesthesia Patient Safety Foundation. He has lectured in the Harvard Business School on healthcare innovation and in the Biomedical Entrepreneurship Program at the Harvard-MIT Program in Health Sciences and Technology. He is Director of Life Sciences at Anglo Scientific at the Royal Institution of Great Britain.
Dr. Dagi received an AB from Columbia University, his MD and MPH degrees from Johns Hopkins, and an MBA from the Wharton School. He was named the Joseph P. Kennedy, Jr., Fellow at Harvard, from which he also received a MTS (jurisprudence). He trained at the Massachusetts General Hospital and the Neurosurgical Unit of the Guy’s, Maudsley and King’s College Hospitals in London, and was a Mendeleyeff Travelling Fellow and a Neuroresearch Foundation Fellow. He worked at the MGH Limbic Diencephalic Laboratory on neuromodulation, and at the NIH on PET scanning under Dr. Louis Sokoloff in the Laboratory for Cerebral Metabolism. He was appointed to the Reserve Council of the United States, and served as a neurosurgeon at the Walter Reed Army Medical Center, combat neurosurgeon and flight surgeon, and faculty in the John Fitzgerald Kennedy School for Special Warfare and the Uniformed Services University of the Health Sciences. He is a fellow of the American Association of Neurological Surgeons, the American College of Surgeons, for which he serves as a spokesman, and, by election, to the College of Critical Care Medicine, reserved for the highest 5% of practitioners in the field.
Dr. Dagi was President of the Georgia Neurosurgical Society, Director of the Georgia Biomedical Association, Founding Director of the Southeast Life Sciences Investor Association, Director of the Medical Development Group in Massachusetts and a Director of the American Association of Neurological Surgeons. He serves as an overseer of the Beth Israel Deaconess Medical Center in Boston and sits on the Research Oversight Committee. Among other distinctions, he has been awarded the US Humanitarian Service Medal, and a DMedSc from Queen’s University Belfast, and a DHC from the Kaunas Technical University in Lithuania for contributions to medicine and public service. He was named the Sir Thomas and Edith Dixon Medalist for 2012 and was named to an ad hominem Fellowship in the Royal College of Surgeons Edinburgh in 2013. In 2015 he was the Distinguished Lecturer in the Space 4 Biomedicine Program of the National Space Biomedical Research Institute (NSBRI) and the Baylor College of Medicine Center for Space Medicine. In 2016 he was named to the advisory board of CURAM, the Science Foundation Ireland Centre for Research in Medical Devices in Galway, Ireland. He is an editor of Neurosurgery, the Journal of Clinical Ethics, and Numanities, and has authored or co-authored over 175 articles and authored or edited several books.
Marc Semigran, MD joined MyoKardia as chief medical officer in December, 2016. Previously, he led the Massachusetts General Hospital Heart Failure and Cardiac Transplant Program as section head and medical director, from 2004 to 2016. In addition, he was principal investigator of the Harvard Regional Clinical Center of the National Heart, Lung, and Blood Institute Heart Failure Network. Dr. Semigran was a member of the internal medicine and cardiology staff of Massachusetts General for more than 25 years and is an associate professor at Harvard Medical School. He has published more than 140 peer-reviewed papers in cardiomyopathy, heart failure and cardiac transplantation, and served as editor for a leading textbook on heart failure. Dr. Semigran is a recipient of numerous National Institutes of Health and industry research awards, and has served as principal or co-investigator in several major clinical trials across various therapeutic areas. In addition, he has served in scientific and medical advisory capacities to such companies as GSK, Medtronic plc and Bayer.
Dr. Semigran earned A.B., A.M. and M.D. degrees from Harvard University. He completed his internal medicine residency and cardiology fellowship training at Massachusetts General.